The National One Health Youth Symposium in Bangladesh (NOHYSB) is a pioneering, youth-led initiative designed to empower undergraduate and early-career professionals to lead the integration of human, animal, and environmental health through the One Health approach. Launched as a response to the urgent need for interdisciplinary collaboration in tackling challenges like antimicrobial resistance (AMR), zoonotic diseases, food safety, and climate-linked health threats, NOHYSB serves as a dynamic platform for awareness, education, innovation, and leadership development.